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Interference with adequate oral electrolyte intake will also contribute to hypokalemiaHypokalemia can sensitize or exaggerate the response of the heart to the toxic effects of digitalise.gincreased ventricular irritability

Potassium-sparing agents should be used very cautiouslyif at allin conjunction with angiotensin-converting enzymeACEinhibitors due to a greatly increased risk of hyperkalemiaSerum potassium should be monitored frequently.

Hydrochlorothiazide was not genotoxic in in vitro assays using strains TA 98TA 100TA 1535TA 1537 and TA 1538 of Salmonella typhimuriumthe Ames testin the Chinese hamster ovaryCHOtest for chromosomal aberrationsor in in vivo assays using mouse germinal cell chromosomesChinese hamster bone marrow chromosomesand the Drosophila sex-linked recessive lethal trait genePositive test results were obtained in the in vitro CHO sister chromatid exchangeclastogenicitytestand in the mouse lymphoma cellmutagenicityassaysusing concentrations of hydrochlorothiazide of 43 to 1300 mcg/mLPositive test results were also obtained in the Aspergillus nidulans nondisjunction assay using an unspecified concentration of hydrochlorothiazide.

This medication can increase your potassium levelsespecially if you have kidney disease or diabetesor are severely illPotassium levels must be done while you are taking this medicationIf not treatedvery high potassium levels can sometimes be fatalIf you notice any of the following serious side effectstell your doctor right awaymuscle weaknessslow/irregular heartbeat.

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triamterene and hydrochlorothiazide may be used alone or as an adjunct to other antihypertensive drugs, such as beta-blockers.

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