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Patients who have low WBC counts because of benign ethnic neutropenia should be given special consideration and may only be started on Clozaril with the agreement of a haematologist.

High doses or long-term use of clozapine can cause a serious movement disorder that may not be reversibleSymptoms of this disorder include uncontrollable muscle movements of your lipstongueeyesfacearmsor legsThe longer you take Clozarilthe more likely you are to develop a serious movement disorderThe risk of this side effect is higher in women and older adults.

Clozaril can lower blood cells that help your body fight infectionsespecially in women and older adultsand in people who are malnourished or have serious medical problemsThis can make it easier for you to develop a serious or life-threatening infectionYour blood will need to be tested oftenYour future treatments may be delayed based on the results of these tests.

Do not stop taking clozapine without consulting your doctorSome conditions may become worse when the drug is suddenly stoppedAlsoyou may experience symptoms such as severe sweatingheadachenauseavomitingand diarrheaTo prevent these symptoms while you are stopping treatment with this drugyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsReport any new or worsening symptoms right away.

As with other antipsychoticscaution should be exercised when clozapine is prescribed with medicines known to increase QTc interval.

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however, concomitant use of clozaril and strong cyp3a4 inducers is not recommended see dosage and administration .

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