Posted on 24.08.2018 in the General category
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Liver problemsloss of appetitestomach painupper right sidedark urineclay-colored stoolsjaundiceyellowing of the skin or eyes
Non-steroidal anti-inflammatory drugsThe C max and AUC of flurbiprofen was increased by 23and 81respectivelywhen coadministered with fluconazole compared to administration of flurbiprofen aloneSimilarlythe C max and AUC of the pharmacologically active isomerSibuprofenwas increased by 15and 82respectivelywhen fluconazole was coadministered with racemic ibuprofen400 mgcompared to administration of racemic ibuprofen alone.
Current labeling for Diflucan and fluconazole products indicates that human studies do not suggest increased risks during pregnancy when women are exposed to single 150mg oral dosageHoweverthe FDA released a warning statement in 2011 warning that high dosessuch as 400-800mg per daymay result in birth abnormalities including brachycephalyflattened rear skulland cleft palateResults from the Danish studyhoweversuggest that even small doses of fluconazolethe standard dose studied was 150mg 1-2 times per daymay increase the risk of miscarriage.
An observational study has suggested an increased risk of spontaneous abortion in women treated with fluconazole during the first trimester.
The U.SFood and Drug AdministrationFDAis currently reviewing a Danish study that indicates popular yeast infection drug Diflucan can cause miscarriagesWhile reviewing the Danish study and other datathe FDA is urging healthcare providers to be cautious when prescribing Diflucanor its generic alternative fluconazoleduring pregnancyHealthcare providers and patients are also urged to report any adverse events that may occur while taking Diflucanor shortly thereafter.
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fluconazole is the fda-approved generic form of brand-name diflucan.
