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These data are derived from two studies in patients with serum theophylline concentrations30 mcg/mLIn the first studyStudy1ShanonAnn Intern Med 1993;119:1161-67data were prospectively collected from 249 consecutive cases of theophylline toxicity referred to a regional poison center for consultationIn the second studyStudy2SesslerAm J Med 1990;88:567-76data were retrospectively collected from 116 cases with serum theophylline concentrations30 mcg/mL among 6000 blood samples obtained for measurement of serum theophylline concentrations in three emergency departmentsDifferences in the incidence of manifestations of theophylline toxicity between the two studies may reflect sample selection as a result of study designe.gin Study148of the patients had acute intoxications versus only 10in Study2and different methods of reporting results.
Check with your doctor immediately if any of the following side effects occur:
Although certain medicines should not be used together at allin other cases two different medicines may be used together even if an interaction might occurIn these casesyour doctor may want to change the doseor other precautions may be necessaryWhen you are taking this medicineit is especially important that your healthcare professional know if you are taking any of the medicines listed belowThe following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Clearance represents the volume of blood completely cleared of theophylline by the liver in one minuteValues listed were generally determined at serum theophylline concentrations 3 months of ageIn contrastthe large fraction of the theophylline dose excreted in the urine as unchanged theophylline and caffeine in neonates requires careful attention to dose reduction and frequent monitoring of serum theophylline concentrations in neonates with reduced renal functionSee WARNINGS
It is best to take the extended-release capsule one hour before a high-fat meal or without food.
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