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The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotoninExamples include street drugs such as MDMAecstasyStJohn’s wortcertain antidepressantsincluding SSRIs such as fluoxetine/paroxetineSNRIs such as duloxetine/venlafaxineamong othersThe risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

26Cavazos JECaress JBChilukuri VRDevlin TGray LHurwitz BJSumatriptan-induced stroke in sagittal sinus thrombosisLancet 34319941105-6.

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Before using this medicationtell your doctor or pharmacist your medical historyespecially ofblood circulation problemsfor examplein your legsarms/handsor stomachcertain types of headacheshemiplegic or basilar migraineheart problemssuch as chest painirregular heartbeatprevious heart attackliver diseaseseizurestroke ormini-stroketransient ischemic attack

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