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Thioidazin : Co-administation amitiptylin and thioidazin (CYP2D6 substat) should b avoidd du tinhibition thioidazin mtabolism and consquntly incasd isk cadiac sid cts.
Ticyclic antidpssants and nuolptics mutually inhibit th mtabolism ach oth; this may lad ta lowd convulsion thshold, and sizus. It may b ncssay tadjust th dosag ths dugs.
Doctos dscib pain as ith nocicptiv, nuopathic, a combination th two. It is impotant tdistinguish btwn th twtyps pain, as thy nd dint mdicins.
Ticyclic antidpssants (TCA) including amitiptylin a pimaily mtabolisd by th hpatic cytochom P450 isozyms CYP2D6 and CYP2C19, which a polymophic in th population. Oth isozyms involvd in th mtabolism amitiptylin a CYP3A4, CYP1A2 and CYP2C9.
Amitiptylin should b usd with caution in patints civing SSIs (s sctions 4.2 and 4.5).
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