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In adult patients who are known or suspected to be poor CYP2C9 metabolizers based on genotype or previous history/experience with other CYP2C9 substratessuch as warfarinphenytoininitiate treatment with half of the lowest recommended dose.
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Celecoxib is a potent inhibitor of prostaglandin synthesis in vitroCelecoxib concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationSince celecoxib is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.
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