Posted on 11.09.2018 in the General category
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Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nauseavomitingsalivationsweatingbradycardiahypotensionrespiratory depressioncollapse and convulsionsIncreasing muscle weakness is a possibility and may result in death if respiratory muscles are involvedAtypical responses in blood pressure and heart rate have been reported with other drugs that increase cholinergic activity when coadministered with quaternary anticholinergics such as glycopyrrolateAdditional symptoms associated with rivastigmine overdose are diarrheaabdominal paindizzinesstremorheadachesomnolenceconfusional statehyperhidrosishypertensionhallucinations and malaiseDue to the short half-life of rivastigminedialysishemodialysisperitoneal dialysisor hemofiltrationwould not be clinically indicated in the event of an overdose.
In generaladverse reactions were less frequent later in the course of treatment.
Exelon is not expected to harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant during treatment.
Caregivers should be advised of the high incidence of nausea and vomiting associated with the use of the drug along with the possibility of anorexia and weight lossCaregivers should be encouraged to monitor for these adverse events and inform the physician if they occurIt is critical to inform caregivers that if therapy has been interrupted for more than several daysthe next dose should not be administered until they have discussed this with the physiciansee WARNINGS AND PRECAUTIONS
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