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Posted on 12.09.2018 in the General category

F 29 amp;m 2326242 learn about imuran from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions.

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Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

Cases of JC virus-associated infection resulting in progressive multifocal leukoencephalopathyPMLsometimes fatalhave been reported in patients treated with immunosuppressantsincluding ImuranRisk factors for PML include treatment with immunosuppressant therapies and impairment of immune functionConsider the diagnosis of PML in any patient presenting with new-onset neurological manifestations and consider consultation with a neurologist as clinically indicatedConsider reducing the amount of immunosuppression in patients who develop PMLIn transplant patientsconsider the risk that the reduced immunosuppression represents to the graft.

Imuran should not be given to patients who are pregnant or likely to become pregnant without careful assessment of risk versus benefit.

Patients with inherited mutated NUDT15 gene are at increased risk for severe azathioprine toxicitysee 4.4These patients generally require dose reductionparticularly those being NUDT15 variant homozygotessee 4.4Genotypic testing of NUDT15 variants may be considered before initiating azathioprine therapyIn any caseclose monitoring of blood counts is necessary.

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