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Indomethacin may interfere with the blood pressure-lowering effects of drugs that are given to reduce blood pressureThis may occur because prostaglandins play a role in the regulation of blood pressure.

A history of heart attackstrokeor blood clotheart diseasecongestive heart failurehigh blood pressurea history of stomach ulcers or bleedingliver or kidney diseasea seizure disorder such as epilepsyasthmapolyps in your nosea bleeding or blood clotting disorderor if you smoke.

Caution is advised when using this drug in the elderly because they may be more sensitive to its side effectsespecially stomach bleeding and kidney problems.

This medicine may cause stomach bleedingDaily use of alcohol and tobaccoespecially when combined with this medicinemay increase your risk for stomach bleedingLimit alcohol and stop smokingConsult your doctor or pharmacist for more information.

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