Posted on 12.09.2018 in the General category
Do not stop taking keppra, or change the dosage, without checking with your doctor.
The use of levetiracetam has been very rarely associated with acute kidney injurywith a time to onset ranging from a few days to several months.
The precise mechanism(sby which levetiracetam exerts its antiepileptic effect is unknownThe antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizuresLevetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold testsProtection was observedhoweveragainst secondarily generalized activity from focal seizures induced by pilocarpine and kainic acidtwo chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalizationLevetiracetam also displayed inhibitory properties in the kindling model in ratsanother model of human complex partial seizuresboth during kindling development and in the fully kindled stateThe predictive value of these animal models for specific types of human epilepsy is uncertain.
35 infants aged less than 1 year with partial onset seizures have been exposed in placebo-control clinical studies of which only 13 were aged.
Potential pharmacokinetic interactions of or with levetiracetam were assessed in clinical pharmacokinetic studiesphenytoinvalproatewarfarindigoxinoral contraceptiveprobenecidand through pharmacokinetic screening in the placebo-controlled clinical studies in epilepsy patients.
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the safety and effectiveness of keppra in the adjunctive treatment of partial onset seizures in pediatric patients age 1 month to 16 years old with epilepsy have been established see clinical studies 14.
