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General This drug is indicated as adjunctive therapy with diuretics and digitalis for treating heart failureFollowing first time MIall ACE inhibitorsat comparable appropriate dosagesappear to be equally effective for reducing mortality and recurrent MI ratesPrior to therapypatients at high risk of symptomatic hypotension such as patients with salt depletion with or without hyponatremiahypovolemia or those receiving vigorous diuretic therapy should have these conditions correctedRenal function and serum potassium should be monitoredIf it is not feasible to discontinue diuretic therapy prior to starting lisinoprilthe patient should be closely monitored for several hours following the initial dose of this drugand until the blood pressure has stabilizedThe antihypertensive effects of lisinopril and diuretics used in combination are approximately additiveAchievement of optimal blood pressure reduction may require 2 to 4 weeks of therapyAcute myocardial infarctionin addition to this drugpatients should receiveif appropriatestandard treatmentssuch as thrombolyticsaspirinand a beta-blockerAntihypertensive effects of this drug are maintained during long-term therapyAbrupt withdrawal has not been associated with a rapid increase in blood pressureor a significant increase in blood pressure compared to pretreatment levels.

Frequency not reportedFatigueastheniaorthostatic effectstinnitusolfactory disturbance.

Talk to your doctoras other medicines might be better while you are breastfeeding.

The following adverse reactions have been identified during post-approval use of lisinopril that are not included in other sections of labelingBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposureOther reactions include:

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in the above pediatric studies, lisinopril was given either as tablets or in a suspension for those children and infants who were unable to swallow tablets or who required a lower dose than is available in tablet form see dosage and administration 2.

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