Posted on 12.09.2018 in the General category
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LIORESAL INTRATHECAL is for use in single bolus intrathecal injectionsvia a catheter placed in the lumbar intrathecal space or injection by lumbar punctureand in implantable pumps approved by the FDA specifically for the intrathecal administration of baclofenBecause of the possibility of potentially life-threatening CNS depressioncardiovascular collapseand/or respiratory failurephysicians must be adequately trained and educated in chronic intrathecal infusion therapy.
Lioresal is not indicated in the treatment of skeletal muscle spasm resulting from rheumatic disorders.
In patients with epilepsythe clinical state and electroencephalogram should be monitored at regular intervalssince deterioration in seizure control and EEG have been reported occasionally in patients taking Lioresal.
Following surgical implantation of the pumpparticularly during the initial phases of pump usethe patient should be monitored closely until it is certain that the patient’s response to the infusion is acceptable and reasonably stable.
Pharmacodynamics of LIORESAL INTRATHECAL Intrathecal BolusAdult PatientsThe onset of action is generally one-half hour to one hour after an intrathecal bolusPeak spasmolytic effect is seen at approximately four hours after dosing and effects may last four to eight hoursOnsetpeak responseand duration of action may vary with individual patients depending on the dose and severity of symptoms.
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lioresal intrathecal can only be given by experienced doctors using special medical equipment.
