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There are several readily identifiable causes of reduced theophylline clearanceIf the total daily dose is not appropriately reduced in the presence of these risk factorssevere and potentially fatal theophylline toxicity can occurCareful consideration must be given to the benefits and risks of theophylline use and the need for more intensive monitoring of serum theophylline concentrations in patients with the following risk factors:
This medicine may add to the central nervous systemCNSstimulant effects of caffeine-containing foods or beverages such as chocolatecocoateacoffeeand cola drinksAvoid eating or drinking large amounts of these foods or beverages while using this medicineIf you have questions about thischeck with your doctor.
Institute supportive careincluding establishment of intravenous accessmaintenance of the airwayand electrocardiographic monitoring.
Other manifestations of theophylline toxicity include increases in serum calciumcreatine kinasemyoglobin and leukocyte countdecreases in serum phosphate and magnesiumacute myocardial infarctionand urinary retention in men with obstructive uropathy.
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