Posted on 12.09.2018 in the General category
Another important drug interaction occurs between statins and niacin and fibric acids, for example, gemfibrozil lopid , clofibrate atromid-s , and fenofibrate tricor .
Mild to moderate hemoglobinhematocritand white blood cell decreases have been observed in patients following initiation of fenofibrate therapyHoweverthese levels stabilize during long-term administrationThrombocytopenia and agranulocytosis have been reported in individuals treated with fenofibratePeriodic monitoring of red and white blood cell counts are recommended during the first 12 months of TRICOR administration.
Baseline and regular periodic monitoring of liver functionincluding serum ALTSGPTshould be performed for the duration of therapy with TRICORand therapy discontinued if enzyme levels persist above three times the normal limit.
TriCor should not be taken by people with livergallbladderor severe kidney diseasenursing mothersor those allergic to any product ingredientTriCor has not been shown to lower your risk of having heart problems or a strokeTriCor can cause muscle problemsUnexplained muscle paintendernessor weakness may be a sign of a serious but rare muscle problem and should be reported to your healthcare provider right awayThe risk of a serious muscle problem may be higher when Tricor is given with statinsIf you take a statin tell your healthcare providerTriCor can cause liver problemsBlood tests are needed before and during treatment with TriCor to check for liver problemsSome people require blood tests to check for kidney problems while taking TriCorTriCor may cause inflammationswellingof the gallbladder or pancreasContact your healthcare provider if you experience abdominal painnauseaor vomitingTell your healthcare provider about all the medicines you takeincluding all prescription and non-prescription medicinesvitamins and herbal supplementsTriCor may cause allergic-type reactionsblood clotsand possible changes in some blood test valuesIf you are pregnant or may become pregnanttalk with your healthcare provider about TriCorIt is not known if TriCor will harm your unborn babyThe most common side effects with TriCor include increases in liver or muscle enzymes measured by blood tests and congestion or allergy-like symptoms in the nose.
The absorption of fenofibrate is increased when administered with foodWith fenofibrate tabletsthe extent of absorption is increased by approximately 35under fed as compared to fasting conditions.
The use of TRICOR has not been evaluated in subjects with hepatic impairmentsee CONTRAINDICATIONS and CLINICAL PHARMACOLOGY
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