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higher plasma insulin, lower serum androstenedione, and less severe menstrual abnormalities are baseline predictors of clinical response to metformin.

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2 mg dl , treatment with metformin hydrochloride tablets up to 2000 mg day for up to 16 weeks mean duration of treatment 11 weeks resulted in a significant mean net reduction in fpg of 64.

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metformin has been shown to decrease the production of inflammatory cytokines, including tnf-a, interleukin-6, and vascular endothelial growth factor, through the inactivation of nf-kb and hif-1a 92 94 .

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