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although it is not known whether the risk would be increased, it is prudent either to avoid clozaril clozapine or use it cautiously in patients with a previous history of agranulocytosis induced by other drugs.
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because of the significant risk of agranulocytosis and seizure associated with its use, clozaril should be used only in patients who have failed to respond adequately to treatment with appropriate courses of standard drug treatments for schizophrenia, either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs.
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clozaril clozapine is not approved for the treatment of patients with dementia -related psychosis see warnings .
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