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In people with cancerhydroxyurea acts as a substitute for some parts that the cancer cells need to growCancer cells take in hydroxyureawhich stops the cancer cell from growingCancer cells grow more rapidly than normal cellsso they are more affected by the drug.
Advise females of reproductive potential to use effective contraception during and after treatment with HYDREA for at least 6 months after therapyAdvise males of reproductive potential to use effective contraception during and after treatment with HYDREA for at least 1 year after therapysee Use in Specific Populations
In the U.Sgeneral populationthe estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 24and 1520respectively.
For people with kidney diseaseThe typical initial dosage of Hydrea and generic hydroxyurea is reduced by 50 percent in people with kidney disease.
Acute mucocutaneous toxicity has been reported in patients receiving hydroxyurea at dosages several times the therapeutic doseSorenessviolet erythemaedema on palms and soles followed by scaling of hands and feetsevere generalized hyperpigmentation of the skinand stomatitis have also been observed.
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hydrea capsules may potentiate some adverse reactions usually seen with irradiation alone, such as gastric distress and mucositis.
