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Frequency of adverse reactions with hydrochlorothiazide.
Upset stomachdizzinessor headache may occur as your body adjusts to the medicationIf any of these effects last or get worsetell your doctor or pharmacist promptly.
Acute antihypertensive effects of thiazides are thought to result from a reduction in blood volume and cardiac outputsecondary to a natriuretic effectalthough a direct vasodilatory mechanism has also been proposedWith chronic administrationplasma volume returns toward normalbut peripheral vascular resistance is decreasedThe exact mechanism of the antihypertensive effect of hydrochlorothiazide is not known.
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