Posted on 24.08.2018 in the General category
Viramune is principally metabolized by the liver via the cytochrome p450 isoenzymes, 3a4 and 2b6.
Limited human data are insufficient to determinerisk of infertility in humansbased on results from animal fertility studies conducted in ratstherapy may reduce fertility in females of reproductive potentialnot known if these effects on fertility are reversible.
It is not recommended to co-administer atazanavir/ritonavir and Viramunesee section 4.4
Initial therapyWhen initiating therapygive immediate-release tablet 200 mg PO qDay for 14 daysthen extended-release tablet 400 mg PO qDay thereafter Switch from immediate-releaseIf already taking immediate-release regimenmay switch to extended-release 400 mg PO qDay without 14-day lead-in period of immediate-release nevirapine.
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the 14-day lead-in period with viramune 200 mg daily dosing must be strictly followed, it has been demonstrated to reduce the frequency of rash see dosage and administration and warnings and precautions .