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No changes to lamivudine apparent clearance and volume of distributionsuggesting no induction effect of nevirapine on lamivudine clearance.
Viramune should not be used as the sole active antiretroviralas monotherapy with any antiretroviral has shown to result in viral resistance.
Boceprevir is partly metabolized by CYP3A4/5Co-administration of boceprevir with medicines that induce or inhibit CYP3A4/5 could increase or decrease exposurePlasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapineThe clinical outcome of this observed reduction of boceprevir trough concentrations has not been directly assessed.
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