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the hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory drugs, clarithromycin, disopyramide, fluoxetine, quinolones and other drugs that are highly protein bound, such as salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
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failure to do so may decrease the effectiveness of chloramphenicol and increase the risk that the bacteria will no longer be sensitive to chloramphenicol and will not be able to be treated by this or certain other antibiotics in the future.
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therefore, most esbl producing organisms are also resistant to aminogylcosides, fluororquinolones, tetracyclines, chloramphenicol, sulfonamides.
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