Posted on 23.08.2018 in the General category
Copegus ribavirin may decrease the number of red blood cells in your body anemia and it can be life-threatening in people who have heart disease or circulation problems.
Alpha interferonsincluding Pegasysmay cause or aggravate fatal or life-threatening neuropsychiatricautoimmuneischemicand infectious disordersPatients should be monitored closely with periodic clinical and laboratory evaluationsPatients with persistently severe or worsening signs or symptoms of these conditions should be withdrawn from therapyIn manybut not all casesthese disorders resolve after stopping Pegasys therapyCopegus may cause birth defectsExtreme care must be taken to avoid pregnancy in female patients and in female partners of male patients taking Pegasys and Copegus combination therapyRibavirin causes hemolytic anemiaThe anemia associated with ribavirin therapy may result in worsening of cardiac disease.
Patient characteristicsOne-hundred-thirty-four patients agreed to participategave a written informed consent and were enrolled in the study97 nonresponders to previous IFN treatment were allocated to group Aand 37 relapsers to previous IFN treatment were allocated to group BBaseline demographicvirological and histological characteristics of patients in the two treatment groups were similarTable 1Overall11183patients were menmedian age was 48 yearsrange 20-7111183patients were Caucasian9672patients were genotype 1 and histological evidence of cirrhosis was observed in 4434patientsBridging fibrosis was observed in 2922patientsAmong patients with non-1 genotype11was genotype 23627were genotype 3 and 11was genotype 4HCV RNA quantification was performed before treatment in 117 patients87.3
A genotype subanalysis of our studied population showed that 17and 44of genotype 1 nonresponders and relapser patientsrespectivelyachieved a SVRAmong the non-1 genotype nonresponders and relapsers46and 70of patients achieved a SVRrespectivelyThe response rate in our non-1 genotype relapsers group was close to what was reported for naive patients submitted to the same therapeutic regimen847
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the most common life-threatening or fatal events induced or aggravated by pegasys and copegus were depression, suicide, relapse of drug abuse overdose, and bacterial infections, each occurring at a frequency of 1 .
