Posted on 13.05.2018 in the General category
People taking methotrexate over extended periods will not notice a problem with an occasional alcoholic beverage.
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elevated methotrexate concentrations were noted in a girl who received oral dantrolene a day before intravenous methotrexate 12 g m2 18 grams .
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among adults who received high-dose methotrexate median dose of 3500 mg m2, range of 1000-5000 mg m2 , coadministration of ppis such as omeprazole, lansoprazole, or rabeprazole was identified as a risk factor for delayed methotrexate elimination with an or of 2.
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methotrexate is an antimetabolite chemotherapeutic agent that binds to the enzyme dihydrofolate reductase, which is involved in the synthesis of purine nucleotides.
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