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In most clinical trials evaluating the effectiveness of naltrexone, subjects who received naltrexone were significantly more successful in remaining abstinent and in avoiding relapse than were those receiving an inactive placebo pill.

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the renal clearance for naltrexone ranges from 30 to 127 ml min and suggests that renal elimination is primarily by glomerular filtration.

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all 3 patients had previously been extensively treated with standard therapies for icrp including diphenhydramine, chlorpheniramine, cholestyramine, rifampicin, phenobarbital, doxepin, naltrexone, uv therapy, and topical lotions.

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another novel use of low dose naltrexone has been for aiding motility in sibo small intestinal bacterial overgrowth .

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