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Hypomagnesemiasymptomatic and asymptomatichas been reported rarely in patients treated with PPIs for at least three monthsin most cases after a year of therapySerious adverse events include tetanyarrhythmiasand seizuresIn most patientstreatment of hypomagnesemia required magnesium replacement and discontinuation of the PPI.

Literature suggests that concomitant use of PPIs with methotrexateprimarily at high dosesee methotrexate prescribing informationmay elevate and prolong serum levels of methotrexate and/or its metabolitepossibly leading to methotrexate toxicitiesIn high-dose methotrexate administration a temporary withdrawal of the PPI may be considered in some patientssee DRUG INTERACTIONS

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Hypomagnesemiasymptomatic and asymptomatichas been reported rarely in patients treated with PPIs for at least three monthsin most cases after a year of therapySerious adverse events include tetanyarrhythmiasand seizuresIn most patientstreatment of hypomagnesemia required magnesium replacement and discontinuation of the PPI.

Erosive Esophagitis Due To Acid-Mediated Gerd In Infants 1 Month To Less Than One Year of Age.

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