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Drugs which induce cytochrome P450 3A4CYP 3A4enzyme activitye.gbarbituratesphenytoincarbamazepinerifampinmay enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increasedDrugs which inhibit CYP 3A4e.gketoconazolemacrolide antibiotics such as erythromycinhave the potential to result in increased plasma concentrations of corticosteroidsDexamethasone is a moderate inducer of CYP 3A4Co-administration with other drugs that are metabolized by CYP 3A4e.gindinavirerythromycinmay increase their clearanceresulting in decreased plasma concentration.
What are the less commonoccur in 10to 29of patientsside effects of treatment with dexamethasone?
Psychic derangements may appear when corticosteroids are usedranging from euphoriainsomniamood swingspersonality changesand severe depressionto frank psychotic manifestationsAlsoexisting emotional instability or psychotic tendencies may be aggravated by corticosteroids.
Diagnostic testing of adrenocortical hyperfunctiontrichinosis with neurologic or myocardial involvementtuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy.
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