Posted on 12.09.2018 in the General category
Use indinavir as directed by your doctor.
4Bleeding Hemophiliacs may experience spontaneous bleeding episodesincluding bruising and bleeding into jointsIt is not clear ifor howprotease inhibitors cause bleedingAny such episodes should be closely monitored.
Indinavir is metabolized by CYP3A4Drugs that induce CYP3A4 activity would be expected to increase the clearance of indinavirresulting in lowered plasma concentrations of indinavirCoadministration of CRIXIVAN and other drugs that inhibit CYP3A4 may decrease the clearance of indinavir and may result in increased plasma concentrations of indinavir.
Initiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:
If indinavir and didanosine are administered concomitantlythey should be administered at least one hour apart on an empty stomachconsult the manufacturer’s product circular for didanosine
Nephrolithiasis/urolithiasis has occurred with CRIXIVAN therapyThe cumulative frequency of nephrolithiasis is substantially higher in pediatric patients29than in adult patients12.4range across individual trials4.7to 34.4The cumulative frequency of nephrolithiasis events increases with increasing exposure to CRIXIVANhoweverthe risk over time remains relatively constantIn some casesnephrolithiasis/urolithiasis has been associated with renal insufficiency or acute renal failurepyelonephritis with or without bacteremiaIf signs or symptoms of nephrolithiasis/urolithiasis occurincluding flank painwith or without hematuria or microscopic hematuriatemporary interruptione.g13 daysor discontinuation of therapy may be consideredAdequate hydration is recommended in all patients treated with CRIXIVANSee ADVERSE REACTIONS and DOSAGE AND ADMINISTRATIONNephrolithiasis/Urolithiasis
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