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Following oral administrationpeak hydrochlorothiazide plasma levels are attained in approximately 2 hoursIt is excreted rapidly and unchanged in the urine.

Cardiovasculartachycardiashortness of breath and chest painorthostatic hypotensionmay be aggravated by alcoholbarbiturates or narcotics

Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma.

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicityRefer to the package insert on lithium before use of such concomitant therapy.

In patients requiring hydrochlorothiazide therapy and in whom hypokalemia cannot be risked therapy may be initiated with MAXZIDE-25 MGIf an optimal blood pressure response is not obtained with MAXZIDE-25 MGthe dose should be increased to two MAXZIDE-25 MG tablets daily as a single doseor one MAXZIDE tablet dailyIf blood pressure still is not controlledanother antihypertensive agent may be addedsee PRECAUTIONSDRUG INTERACTIONS

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