Posted on 12.09.2018 in the General category
Zyvox is an oxazolidinone antibiotic indicated to treat children and adults with susceptible vancomycin-resistant e.
Hepatic via oxidation of the morpholine ringresulting in 2 inactive metabolitesaminoethoxyacetic acidhydroxyethyl glycinedoes not involve CYP.
Avoid coadministration with serotonergic psychiatric drugsegSSRIsSNRIsTCAsMAOIsunless indicated for life-threatening or urgent infectionsegvancomycin-resistant enterococcal infectionsnosocomial pneumoniacomplicated skin and skin structure infections such as methicillin-resistant S aureusdue to increased risk of serotonin syndromelinezolid may increase serotonin CNS levels by MAO-A inhibition If linezolid must be administered to a patient currently taking a serotonergic drugstop serotonergic drug immediately and monitor for CNS toxicityserotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring5 weeks if fluoxetine was takenwhichever comes firstserotonergic psychiatric medications should be stopped at least 2 weeks in advance of linezolid therapyfluoxetine should be stopped at least 5 weeks in advance due to longer half-life.
FDA pregnancy category CIt is not known whether linezolid is harmful to an unborn babyTell your doctor if you are pregnant or plan to become pregnant during treatment.
The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotoninExamples include street drugs such as MDMAecstasyStJohn’s wortcertain antidepressantsincluding mirtazapineSSRIs such as fluoxetine/paroxetineSNRIs such as duloxetine/venlafaxinetramadolcertaintriptansused to treat migraine headachessuch as rizatriptansumatriptanzolmitriptanamong othersThe risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
Zyvox injection is given as an infusion into a veinA healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
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zyvox is steeped in a cut or impressive opening.
