Posted on 11.09.2018 in the General category
The inhibitory effect of atorlip-f atorvastatin on hmg-coa reductase by about 70 determined by the activity of its circulating metabolites.
Hmodialysis : Whil studis hav not bn conductd in patints with nd-stag nal disas, hmodialysis is not xpctd tsigniicantly nhanc claanc atovastatin sinc th dug is xtnsivly bound tplasma potins.
Hypsnsitivity tatovastatin, clopidogl any componnt this mdication Activ liv disas, which may includ unxplaind psistnt lvations in hpatic tansaminas lvls Activ pathological blding such as pptic ulc intacanial hmohag Womn wha pgnant may bcom pgnant Lactation.
Clopidogl is a thinopyidin class inhibitP2Y12 adnosin diphosphat (ADP) platlt cptos. It is an inhibitplatlt activation and agggation though th ivsibl binding its activ mtabolit tth P2Y12 class ADP cptos on platlts.
Thombolytics: Th saty th concomitant administation clopidogl, ibin non-ibin spciic thombolytic agnts and hpains was assssd in patints with acut myocadial inaction. Th incidnc clinically signiicant blding was simila tthat obsvd whn thombolytic agnts and hpain a co-administd with aspiin.
Gapuit Juic: Contains on mcomponnts that inhibit CYP3A4 and can incas plasma concntations atovastatin, spcially with xcssiv gapuit juic consumption (>1.2 lits/day).
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