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when switching patients to cardizem cd ensure that the patient understands that this is a once daily product, particularly if they were previously on a twice daily product.
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although cardizem has a negative inotropic effect in isolated animal tissue preparations, hemodynamic studies in humans with normal ventricular function have not shown a reduction in cardiac index nor consistent negative effects on contractility dp dt .
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cardizem 60-mg scored tablets are supplied in bottles of 100 ndc 0187-0772-47 .
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in man, cardizem prevents spontaneous and ergonovine-provoked coronary artery spasm.
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Patients taking other drugs that are substrates of cyp450 3a4, especially patients with renal and or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered cardizem in order to maintain optimum therapeutic blood levels.
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