Posted on 11.09.2018 in the General category
Patients receiving treatment with cytoxan have an increased risk of developing malignancies including leukemia, bladder cancer, and other tumors.
The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.
Cyclophosphamide can cause fetal harm when administered to a pregnant woman and such abnormalities have been reported following cyclophosphamide therapy in pregnant womenAbnormalities were found in two infants and a six-month-old fetus born to women treated with cyclophosphamideEctrodactylia was found in two of the three casesNormal infants have also been born to women treated with cyclophosphamide during pregnancyincluding the first trimesterIf this drug is used during pregnancyor if the patient becomes pregnant while takingreceivingthis drugthe patient should be apprised of the potential hazard to the fetusWomen of childbearing potential should be advised to avoid becoming pregnant.
Cyclophosphamide also works by decreasing your immune system’s response to various diseasesIt is used to treat a certain type of kidney disease in children after other treatments have not worked.
Nauseavomitingloss of appetitestomach achediarrheaor darkening of the skin/nails may occurNausea and vomiting can be severeIn some casesdrug therapy may be necessary to prevent or relieve nausea and vomitingChanges in diet such as eating several small meals or limiting activity may help lessen some of these effectsIf these effects persist or worsennotify your doctor or pharmacist promptly.
Granulomatosis with polyangiitissevere rheumatoid arthritislupus erythematosusadvanced mycosis fungoidesand several of forms of vasculitis.
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