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disopyramide moderate cyp3a4 inhibitors, such as isoniazid, may increase serum plasma concentrations of disopyramide, a cyp3a4 substrate.

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the diagnosis of extensively drug-resistant tb xdr-tb is established with an isolate that is resistant to isoniazid, rifampin, at least 1 of the quinolones, and at least 1 injectable drug.

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for specific information on the agents used in the management of rifampin, isoniazid, pyrazinamide, and ethambutol overdose, see pyridoxine systemic in monograph;.

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